The Bariatric Interest Group includes:
- Principal investigators: Drs. Domenico Accili, Paul Berk, Michael
Devlin, Wendy Chung, Susan Carnell, Ilene Fennoy, Dympna Gallagher, Alan
Geliebter, Paul Harris, Joy Hirsh, Kathleen Keller, Judy Korner, Donald
Kotler, Blandine Laferrère, Rudy Leibel, Christopher Ochner, Xavier
Pi-Sunyer, Gary Schwartz
- Surgeons: Drs. Scott Belsley, Grace Kim, Ninan Koshy, James McGinty and
Julio Teixeira at St. Luke’s-Roosevelt Hospital Center (SLRHC) and Drs. Mark
Bessler, Daniel Davis, Beth Schrope,
Akuezunkpa Ude, and Jeffrey Zistman (adolescents surgery), at Columbia
University Medical Center (CUMC).
Research and procedures: Bariatric surgery results in
significant and sustained weight loss, with considerable clinical improvement in
obesity-associated comorbidities and diabetes remission in up to 80% of cases.
The investigators in the Bariatric Interest Group are trying to understand the
mechanisms of sustained weight loss and improved metabolism after various
bariatric surgical procedures. We have 2 very active bariatric programs, one
based at SLRHC and the other one at CUMC, with a total of 10 surgeons who
perform between them ~ 800 yearly bariatric procedures, all laparoscopic:
- gastric bypass (60%)
- gastric banding (20%)
- vertical sleeve gastrectomy (20%).
About 50 adolescent bariatric surgeries are performed each year by our
Both bariatric centers are “Centers of Excellence” with high quality pre- and
postoperative care and excellent clinical outcomes, monitored long term. The
bariatric centers are essential to NYONRC clinical research studies,
facilitating recruitment and allowing access to useful biospecimens (urine,
blood, adipose tissue, liver, gastric and small bowel mucosa).
The interest group’s research interests range across virtually all aspects of
the NYONRC’s activities, and make use of almost all Cores’ services.
Specific research projects during the past cycle, and
anticipated in the next cycle, include:
- Fatty acid fluxes in adipocytes and liver (P. Berk), liver
steatosis (P. Berk, D. Kotler)
- Randomization studies comparing different types of surgeries on
diabetes outcome, coupled with glucose and insulin physiological studies (B.
- Mechanisms of diabetes remission: incretins, gastric emptying,
intestinal transit time (B. Laferrère)
- Role of bile acids after gastric bypass surgery (B. Laferrère)
- Gut microbiota and inflammation after bariatric surgery (B. Laferrère)
- Meal pattern and gut peptide (GLP-1, GIP, PYY, ghrelin, CCK)
response to mixed meal (B. Laferrère, J. Korner, A. Geliebter, F.X.
- Safety and effectiveness of bariatric surgery in patients with diabetes
and BMI< 35 kg/m2, randomization study GBP versus diet and intensive
behavior management (J. Korner)
- Brain activation by fMRI in response to meals (A. Geliebter, S.
Carnell, C. Ochner)
- Molecular physiology of the adipocyte from different depots (Y.
- Use of next-generation sequencing and copy-number variation analysis in
adults (LABS at CUMP and SLRHC) and children (Teen-LABS) with extreme
obesity (W. Chung). Study of gut brain interaction: development of
bypass surgical models in rodent (G. Schwartz)
- Change in FOX1 gut expression in DIO rodent models and obese humans
after bypass surgery (D. Accili, G. Schwartz, B. Laferrère)
- Leptin administration in failure after bariatric surgery (J. Korner, R.
- Stomach capacity, gastric stimulation and brain activation (J. Korner,
- Body composition, fat mass, FFM and organ mass and energy expenditure
- The NIDDK’s Longitudinal Assessment of Bariatric Surgery (LABS) study in
adults (P. Berk) and adolescents (J. Zistman, I. Fennoy)
Publications and Grants: With the very active and innovative
surgical teams at SLRHC and CUMC, and the additional presence of the Chair of
the NIH LABS (Dr.Berk), the bariatric interest group of the NYONRC has been
extremely productive in basic, molecular genetics, animal and clinical research,
with a total of 26 grants, and over 77 publications. Strong collaborations exist
and/or are being developed not only among ORC investigators, but also with
national and international scientists. It is expected that the number of funded
projects around the bariatric theme will grow in strength, with both clinical
and basic studies in the coming years.
Bariatric Minimally invasive surgery- St Luke’s Roosevelt Hospital Center
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